{"id":2666,"date":"2024-05-14T09:26:21","date_gmt":"2024-05-14T07:26:21","guid":{"rendered":"https:\/\/xenico.pl\/urydyna\/"},"modified":"2024-05-24T15:03:12","modified_gmt":"2024-05-24T13:03:12","slug":"uridine","status":"publish","type":"post","link":"https:\/\/xenico.pl\/en\/uridine\/","title":{"rendered":"Uridine"},"content":{"rendered":"<div id=\"ez-toc-container\" class=\"ez-toc-v2_0_82_2 counter-hierarchy ez-toc-counter ez-toc-grey ez-toc-container-direction\">\n<div class=\"ez-toc-title-container\">\n<p class=\"ez-toc-title\" style=\"cursor:inherit\">Contents<\/p>\n<span class=\"ez-toc-title-toggle\"><a href=\"#\" class=\"ez-toc-pull-right ez-toc-btn ez-toc-btn-xs ez-toc-btn-default ez-toc-toggle\" aria-label=\"Toggle Table of Content\"><span class=\"ez-toc-js-icon-con\"><span class=\"\"><span class=\"eztoc-hide\" style=\"display:none;\">Toggle<\/span><span class=\"ez-toc-icon-toggle-span\"><svg style=\"fill: #999;color:#999\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" class=\"list-377408\" width=\"20px\" height=\"20px\" viewBox=\"0 0 24 24\" fill=\"none\"><path d=\"M6 6H4v2h2V6zm14 0H8v2h12V6zM4 11h2v2H4v-2zm16 0H8v2h12v-2zM4 16h2v2H4v-2zm16 0H8v2h12v-2z\" fill=\"currentColor\"><\/path><\/svg><svg style=\"fill: #999;color:#999\" class=\"arrow-unsorted-368013\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" width=\"10px\" height=\"10px\" viewBox=\"0 0 24 24\" version=\"1.2\" baseProfile=\"tiny\"><path d=\"M18.2 9.3l-6.2-6.3-6.2 6.3c-.2.2-.3.4-.3.7s.1.5.3.7c.2.2.4.3.7.3h11c.3 0 .5-.1.7-.3.2-.2.3-.5.3-.7s-.1-.5-.3-.7zM5.8 14.7l6.2 6.3 6.2-6.3c.2-.2.3-.5.3-.7s-.1-.5-.3-.7c-.2-.2-.4-.3-.7-.3h-11c-.3 0-.5.1-.7.3-.2.2-.3.5-.3.7s.1.5.3.7z\"\/><\/svg><\/span><\/span><\/span><\/a><\/span><\/div>\n<nav><ul class='ez-toc-list ez-toc-list-level-1 ' ><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-1\" href=\"https:\/\/xenico.pl\/en\/uridine\/#uridine-%e2%80%93-source-and-absorption\" >Uridine \u2013 source and absorption<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-2\" href=\"https:\/\/xenico.pl\/en\/uridine\/#uridine-%e2%80%93-health-benefits\" >Uridine \u2013 health benefits<\/a><\/li><li class='ez-toc-page-1 ez-toc-heading-level-2'><a class=\"ez-toc-link ez-toc-heading-3\" href=\"https:\/\/xenico.pl\/en\/uridine\/#uridine-%e2%80%93-dosage\" >Uridine \u2013 dosage<\/a><\/li><\/ul><\/nav><\/div>\n<p>Uridine belongs to the group of pyrimidine nucleotides, which are ingredients of nucleic acids. It is made of uracil, nitrogenous basis and ribose. Uridine is associated with maintaining body homeostasis and it regulates glucose, lipid and amino acid metabolism and other vital processes. Uridine occurs in the highest numbers from among all pyrimidine products.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"uridine-%e2%80%93-source-and-absorption\"><\/span>Uridine \u2013 source and absorption<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Uridine is produced in the liver in some amounts. Uridine-rich products include (beef and pork) liver, beer yeast, beer, oats, fish (particularly herring), mushrooms (common mushrooms and boletus mushrooms) and vegetables, in particular cabbages and broccoli. Uridine is absorbed from the alimentary tract by diffusion or by specific uridine transporters. The substance is more bioavailable in the form of uridine monophosphate, or uridine nucleotide combined with phosphate residue, compared to pure uridine. Uridine levels are regulated by different factors: eating habits, uridine phosphorylase (UPase) and ATP depletion.<\/p>\n<figure id=\"attachment_2543\" aria-describedby=\"caption-attachment-2543\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-2543\" src=\"https:\/\/xenico.pl\/wp-content\/uploads\/2024\/05\/urydyna-warzywa.jpg\" alt=\"urydyna\" width=\"600\" height=\"375\" srcset=\"https:\/\/xenico.pl\/wp-content\/uploads\/2024\/05\/urydyna-warzywa.jpg 800w, https:\/\/xenico.pl\/wp-content\/uploads\/2024\/05\/urydyna-warzywa-380x238.jpg 380w, https:\/\/xenico.pl\/wp-content\/uploads\/2024\/05\/urydyna-warzywa-250x156.jpg 250w, https:\/\/xenico.pl\/wp-content\/uploads\/2024\/05\/urydyna-warzywa-768x480.jpg 768w, https:\/\/xenico.pl\/wp-content\/uploads\/2024\/05\/urydyna-warzywa-450x281.jpg 450w, https:\/\/xenico.pl\/wp-content\/uploads\/2024\/05\/urydyna-warzywa-600x375.jpg 600w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-2543\" class=\"wp-caption-text\">Uridine-rich products include (beef and pork) liver, beer yeast, beer, oats, fish (particularly herring), mushrooms (common mushrooms and boletus mushrooms) and vegetables, in particular cabbages and broccoli.<\/figcaption><\/figure>\n<h2><span class=\"ez-toc-section\" id=\"uridine-%e2%80%93-health-benefits\"><\/span>Uridine \u2013 health benefits<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>Uridine participates in galactose transformation. In the form of uridine diphosphate glucose (UDP-glucose), it is the donor of glucose molecules used in glycogen synthesis. Phosphatidylcholine, one of the major membrane-building lipids \u2013 including nervous cell membranes, is formed from uridine. In turn, phosphatidylcholine underlies acetylcholine, neurotransmitter which is responsible for memorisation, for instance. Delivering phosphatidylcholine, uridine helps not only create membranes, but also dendrites (nervous branches), which may promote synaptic function. It has been shown that supplementation with uridine supports the process of memorising new information and its recall later on. In addition, taking uridine with choline improves logical thinking and visual memory. One study has shown that uridine can boost cognitive function even in patients with damaged hippocampus. Furthermore, clinical trials have proven that supplementation with uridine improves sleep quality. uridine and its derivatives also reduce cytotoxicity and inhibit drug-induced liver fat buildup.<\/p>\n<figure id=\"attachment_2545\" aria-describedby=\"caption-attachment-2545\" style=\"width: 600px\" class=\"wp-caption aligncenter\"><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-2545\" src=\"https:\/\/xenico.pl\/wp-content\/uploads\/2024\/05\/urydyna-komorka-nerwowa.jpg\" alt=\"urydyna-komorka-nerwowa\" width=\"600\" height=\"375\" srcset=\"https:\/\/xenico.pl\/wp-content\/uploads\/2024\/05\/urydyna-komorka-nerwowa.jpg 800w, https:\/\/xenico.pl\/wp-content\/uploads\/2024\/05\/urydyna-komorka-nerwowa-380x238.jpg 380w, https:\/\/xenico.pl\/wp-content\/uploads\/2024\/05\/urydyna-komorka-nerwowa-250x156.jpg 250w, https:\/\/xenico.pl\/wp-content\/uploads\/2024\/05\/urydyna-komorka-nerwowa-768x480.jpg 768w, https:\/\/xenico.pl\/wp-content\/uploads\/2024\/05\/urydyna-komorka-nerwowa-450x281.jpg 450w, https:\/\/xenico.pl\/wp-content\/uploads\/2024\/05\/urydyna-komorka-nerwowa-600x375.jpg 600w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><figcaption id=\"caption-attachment-2545\" class=\"wp-caption-text\">Uridine participates in galactose transformation. In the form of uridine diphosphate glucose (UDP-glucose).<\/figcaption><\/figure>\n<p>Uridine has been reported to regulate the mitochondrial respiratory chain with the enzyme called dihydroorotate dehydrogenase (DHODH). Mitochondrial dysfunction is one of the causes of various diseases, so uridine can be used as a therapeutic agent in mitochondrial diseases. The said compound participates, for instance, in formation of new connections between nervous cells. Even though pyrimidine nucleotides, including uridine, do not exhibit a direct analgesic or anti-inflammatory effect, they have been shown to improve patient status in the peripheral nervous system in the case of nerve damage. Studies with animals with induced crushing injury have shown that administration of nucleotides speeds up repair of the axons and myelin sheath of regenerating nervous and muscular fibres, which resulted in better conduction rate in nervous fibres. Pre-clinical studies have shown that nucleotide administration is followed by increase in the surface are and thickness of axonal myelin, increase in the number of neuritic protein neurofilaments and increase in the concentration of phospholipids of the neural cell membrane, phosphatidylethanolamine and phosphatidylcholine. Uridine is a biologically active molecule within the brain, and affects both the brain structures and functions. Aside from the formation of the neuronal membrane, uridine interacts with specific uridine-nucleotide receptors (P2Y2 brain receptors), which deal with neuronal differentiation control. The P2Y2 receptor involves structural patterns that promote interactions with the receptors of the growth factor, whose stimulation activates NGF\/TrkA signaling, which in turn has neuroprotective effect. Such properties are beneficial in the context of neurodegenerative disorders, including Alzheimer\u2019s disease, and uridine deficiency may result from neurological symptoms. Studies have shown that patients with Alzheimer\u2019s disease have lower plasma\/brain uridine levels compared to healthy individuals at similar age. A controlled study on 17 healthy individuals have shown that administration of uridine increases brain membrane phospholipid precursors, which may have a positive effect on cognitive function.<\/p>\n<p>In their study on 212 patients with carpal tunnel syndrome treated with the combination of uridine monophosphate, folic acid and vitamin B12, Negr\u00e3o et al. observed pain reduction from pain score of 17.5 down to 8.8 over 2 months and NSAID administration was reduced or discontinued in 77.4% of the patients. The conclusion is that the said substances, if administered in combination, reduce the intensity and extent of the affected areas and pain radiation. Moreover, a 6-week uridine supplementation (500 mg two times a day) in children with bipolar affective disorder led to considerable relief of depressive symptoms compared to baseline.<\/p>\n<h2><span class=\"ez-toc-section\" id=\"uridine-%e2%80%93-dosage\"><\/span>Uridine \u2013 dosage<span class=\"ez-toc-section-end\"><\/span><\/h2>\n<p>The recommended dose of pure uridine, uridine monophosphate and triacetyluridine is 500\u20131,000, 250\u2013500 mg and 25\u2013100 mg per day, respectively.<\/p>\n<p><em style=\"font-size: 14px;\">Bibliography:<\/em><br \/>\n<em style=\"font-size: 14px;\">Arbour CA, Imperiali B. Uridine natural products: Challenging targets and inspiration for novel small molecule inhibitors. Bioorg Med Chem. 2020 Sep 15;28(18):115661. <\/em><br \/>\n<em style=\"font-size: 14px;\">Durka-K\u0119sy M., St\u0119pie\u0144 A.:Rola witamin z grupy B oraz monofosforanu urydyny <\/em><em style=\"font-size: 14px;\">\u2013 substancji od\u017cywczych w leczeniu b\u00f3lu neuropatycznego. B. \u0141oza. Neuropsychiatria. ISSN 2080-4091. VOL. 10 (NR 1)\/2018. <\/em><br \/>\n<em style=\"font-size: 14px;\">Mibielli MAN, Nunes CP, Goldberg H, Buchman L, Oliveira L, Mezitis SGE, Wajnzstajn F, Kaufman R, Nigri R, Cytrynbaum N, Cunha KS, Santos A, Goldberg SW, Platenik NC, Rzetelna H, Futuro DB, Da Fonseca AS, Geller M. Nucleotides Cytidine and Uridine Associated with Vitamin B12 vs B-Complex Vitamins in the Treatment of Low Back Pain: The NUBES Study. J Pain Res. 2020 Oct 13;13:2531-2541<\/em><br \/>\n<em style=\"font-size: 14px;\">https:\/\/examine.com\/supplements\/uridine\/research\/#PlYgaQm-sources-and-structure-1<\/em><br \/>\n<em style=\"font-size: 14px;\">Baumel BS, Doraiswamy PM, Sabbagh M, Wurtman R. Potential Neuroregenerative and Neuroprotective Effects of Uridine\/Choline-Enriched Multinutrient Dietary Intervention for Mild Cognitive Impairment: A Narrative Review. Neurol Ther. 2021 Jun;10(1):43-60. <\/em><br \/>\n<em style=\"font-size: 14px;\">Zhang Y, Guo S, Xie C, Fang J. Uridine Metabolism and Its Role in Glucose, Lipid, and Amino Acid Homeostasis. Biomed Res Int. 2020 Apr 14;2020:7091718.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Uridine belongs to the group of pyrimidine nucleotides, which are ingredients of nucleic acids. It is made of uracil, nitrogenous basis and ribose. Uridine is associated with maintaining body homeostasis<\/p>\n","protected":false},"author":1,"featured_media":2542,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[163,159],"tags":[162],"class_list":["post-2666","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-uridine","category-urydyna","tag-urydyna-en"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Uridine - Xenico Pharma\u00ae<\/title>\n<meta name=\"description\" content=\"Uridine participates in galactose transformation. 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